Fig. 4: S-specific T-cells are phenotypically diverse but similar between groups and over time. | npj Vaccines

Fig. 4: S-specific T-cells are phenotypically diverse but similar between groups and over time.

From: SARS-CoV-2-specific immune responses converge in kidney disease patients and controls with hybrid immunity

Fig. 4

a t-SNE-based dimensional reduction plot of concatenated T-cells, clustered based on the relative expression of phenotypic, memory, activation, inhibition and senescence markers, color coded per cluster. b Heatmap of relative marker expression per cluster. c) Populations of naive and memory CD4+ and CD8+ T-cells, and γδT-cells are outlined based on differential expression of CD4, CD8, TCRγδ, CD45RA and CCR7 shown by the mean fluorescent intensity (MFI). d Distribution of concatenated T-cells per patient group. e S-specific CD4+ , CD8+ T-cells and γδT-cells are overlayed and color coded per patient group or f per time point. g The frequency of memory CD4+ and h) CD8+ T-cells. The symbols, central line, box and whiskers represent individual patients, mean, interquartile range and minumum and maximum values, respectively. Significant differences calculated by Mann-Whitney-U test are indicated (*p < 0.05 and ***p < 0.005).

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