Table 6 Proportion of participants with a 4-fold or greater increase from baseline-PP analyses

From: A randomised trial of malaria vaccine R21/Matrix-M™ with and without antimalarial drugs in Thai adults

Arm

Month 1 n (%)

Month 2 n (%)

Month 3 n (%)

Month 6 n (%)

C-Term

Group 1

47/47 (100)

50/50 (100)

49/49 (100)

48/48 (100)

Group 2

48/49 (98)

48/48 (100)

48/48 (100)

48/48 (100)

Group 3

2/18 (11)

4/19 (21)

6/18 (33)

1/18 (6)

NANP6

Group 1

50/50 (100)

50/50 (100)

50/50 (100)

48/48 (100)

Group 2

50/50 (100)

50/50 (100)

49/49 (100)

48/48 (100)

Group 3

2/20 (10)

4/20 (20)

5/20 (25)

2/20 (10)

Full length R21

Group 1

45/45 (100)

48/48 (100)

48/48 (100)

46/46 (100)

Group 2

47/47 (100)

47/47 (100)

46/46 (100)

45/45 (100)

Group 3

6/18 (33)

3/18 (17)

6/18 (33)

3/16 (19)

Hepatitis B surface antigen

Group 1

15/48 (31)

14/47 (30)

30/48 (63)

17/47 (36)

Group 2

13/49 (27)

20/49 (41)

33/49 (67)

18/48 (38)

Group 3

0/20 (0)

0/20 (0)

0/20 (0)

1/20 (5)

  1. Group 1 = R21/Matrix-M™ + DHA-PIP + SLD-PQ n = 50, Group 2 = R21/Matrix-M™ n = 50, Group 3 = No vaccine n = 20; six repeats of the central NANP6 region sequence (NANP), C-terminal end (C-term), and the full-length vaccine (R21).