Fig. 3: Differential T cell responses to non-structural proteins in VBT cases and unvaccinated TBE patients. | npj Vaccines

Fig. 3: Differential T cell responses to non-structural proteins in VBT cases and unvaccinated TBE patients.

From: Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins

Fig. 3

A–E TBEV-specific IFN-γ spot forming units (SFU) per 1 × 106 PBMC after stimulation with peptide pools derived from structural (A, B) and non-structural (C–E) TBEV proteins after vaccination, TBE, VBT TBE or unexposed subjects. The sum of individual values obtained with peptide pools per TBEV protein was used to calculate the response to each protein. Each dot represents single study participant and the horizontal lines indicate median values. Dashed lines indicate cut-off values for positive responses as detailed in the methods section. Two-tailed Kruskal–Wallis test or One-way ANOVA with multiple comparison tests was performed for comparisons of groups. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Back to article page