Fig. 2: Structural information on AdcA from E. faecium and epitope identification. | npj Vaccines

Fig. 2: Structural information on AdcA from E. faecium and epitope identification.

From: A rationally designed antigen elicits protective antibodies against multiple nosocomial Gram-positive pathogens

Fig. 2

A Domain composition of AdcA based on PFAM analysis. B Cartoon representation of the homology model of full-length AdcA, computed with MODELLER using the structure of AdcA from S. pneumoniae (PDB code: 7jj9, sequence identity 65%) as a template. The ZnuA domain, formed by Lobe 1 (light grey) and Lobe 2 (light blue) is connected to the ZinT domain (violet) through a loop, represented in green. The two zoom panels report putative Zn-binding histidines, represented in stick, in each domain. C Epitope prediction using BepiPred (top) and Discotope (bottom); the region with highest score is coloured blue. D Cartoon and stick representation of the most antigenic region, here named as EH-motif, located in Lobe 1 of the ZnuA domain.

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