Fig. 8: Biotyper Sirius analyses of compound feature significance. | npj Vaccines

Fig. 8: Biotyper Sirius analyses of compound feature significance.

From: Using matrix assisted laser desorption ionisation mass spectrometry combined with machine learning for vaccine authenticity screening

Fig. 8

a Variable importance in the projection (VIP) of the peaks at m/z 0–900 for the Engerix B vaccine compared to the eight falsified constituents. The top 15 m/z values are plotted based on their VIP score. The heatmaps to the right of the plot represent the relative intensities of the m/z values for each sample group averaged over the group. b Two-way analysis of variance (ANOVA) with Dunnett multiple comparison test results for the top 15 m/z values from the VIP analysis. m/z values with at least one statistically significant comparison (P < 0.05) for a falsified constituent compared to Engerix B are marked with a check.

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