Table 2 Summary of PBNA results across laboratories
From: WHO International Standards for antibodies to HPV6 HPV11 HPV31 HPV33 HPV45 HPV52 and HPV58
PBNA | Sample | n/N* | Overall GM titer | %GCV | Max:Min | n/N | Overall GM relative potency | %GCV | Max:Min |
|---|---|---|---|---|---|---|---|---|---|
Antibody | |||||||||
HPV6 | F-Candidate standard | 8/8 | 274 | 126 | 12.9 | 8/8 | 1 | 0 | 1 |
X-Pooled 9v vaccinee serum | 8/8 | 9437 | 217 | 35.9 | 8/8 | 34.40 | 93 | 5.9 | |
H- Natural infection | 8/8 | 112 | 121 | 12.1 | 8/8 | 0.41 | 76 | 5.4 | |
G- Natural infection** | 5/8 | 88 | 137 | 8.9 | 5/8 | 0.23 | 53 | 3.0 | |
HPV11 | G-Candidate standard** | 6/8 | 245 | 203 | 19.3 | 6/8 | 1 | 0 | 1 |
X-Pooled 9v vaccinee serum | 8/8 | 11673 | 348 | 78.2 | 6/8 | 83.32 | 54 | 3.4 | |
HPV31 | N-Candidate standard | 7/8 | 113 | 63 | 3.8 | 7/8 | 1 | 0 | 1 |
X-Pooled 9v vaccinee serum | 8/8 | 6810 | 92 | 7.3 | 7/8 | 60.31 | 144 | 10.1 | |
I- Pooled 2v vaccinee plasma duplicate | 8/8 | 518 | 93 | 5.9 | 7/8 | 5.19 | 51 | 3.2 | |
P- Pooled 2v vaccinee plasma duplicate | 8/8 | 624 | 80 | 4.0 | 7/8 | 5.98 | 35 | 2.3 | |
C- natural infection | 6/8 | 73 | 57 | 3.2 | 5/8 | 0.75 | 29 | 2.0 | |
HPV33 | A-Candidate standard duplicate | 8/8 | 312 | 106 | 7.3 | 8/8 | 1 | 0 | 1 |
J-Candidate standard | 8/8 | 304 | 92 | 5.6 | 8/8 | 0.97 | 13 | 1.5 | |
X-Pooled 9v vaccinee serum | 8/8 | 22715 | 115 | 14.6 | 8/8 | 72.71 | 45 | 2.8 | |
I- Pooled 2v vaccinee plasma duplicate | 7/8 | 92 | 137 | 10.3 | 7/8 | 0.26 | 60 | 4.5 | |
P- Pooled 2v vaccinee plasma duplicate | 8/8 | 86 | 124 | 9.4 | 8/8 | 0.28 | 61 | 4.5 | |
C-Natural infection | 8/8 | 674 | 104 | 7.6 | 8/8 | 2.16 | 48 | 4.0 | |
G- Natural infection** | 8/8 | 158 | 71 | 4.1 | 8/8 | 0.51 | 53 | 3.4 | |
HPV45 | O-Candidate standard | 6/9 | 96 | 99 | 6.6 | 6/9 | 1 | 0 | 1 |
X-Pooled 9v vaccinee serum | 9/9 | 6983 | 149 | 19.4 | 6/9 | 71.31 | 122 | 10.1 | |
I- Pooled 2v vaccinee plasma duplicate | 8/9 | 111 | 114 | 10.9 | 6/9 | 1.39 | 69 | 4.4 | |
P- Pooled 2v vaccinee plasma duplicate | 7/9 | 109 | 93 | 4.8 | 6/9 | 1.03 | 52 | 3.1 | |
HPV52 | B-Candidate standard | 8/8 | 476 | 97 | 9.2 | 8/8 | 1 | 0 | 1 |
K-Candidate standard | 8/8 | 466 | 102 | 10.3 | 8/8 | 0.98 | 15 | 1.5 | |
X-Pooled 9v vaccinee serum | 8/8 | 7831 | 126 | 11.7 | 8/8 | 16.46 | 63 | 4.8 | |
C-Natural infection | 7/8 | 142 | 48 | 3.1 | 7/8 | 0.25 | 33 | 2.0 | |
D natural infection | 7/8 | 132 | 117 | 6.1 | 7/8 | 0.28 | 106 | 7.7 | |
G natural infection | 7/8 | 56 | 68 | 5.3 | 7/8 | 0.10 | 76 | 6.5 | |
HPV58 | L-Candidate standard | 8/8 | 803 | 120 | 6.7 | 8/8 | 1 | 0 | 1 |
X-Pooled 9v vaccinee serum | 8/8 | 9924 | 112 | 8.8 | 8/8 | 12.35 | 103 | 7.3 |
