Fig. 4: Shelf-life stability of SARS-CoV-2 variant RBD-NPs. | npj Vaccines

Fig. 4: Shelf-life stability of SARS-CoV-2 variant RBD-NPs.

From: Potent neutralization of SARS-CoV-2 variants by RBD nanoparticle and prefusion-stabilized spike immunogens

Fig. 4

A Summary of SDS-PAGE and nsEM stability data over 4 weeks. N/A, not assessed. Cocktail formulations include Wu-1-RBD-NP formulated with β-RBD-NP, βRpk9-RBD-NP, γ-RBD-NP, or γRpk9-RBD-NP. Detailed RBD-NP construct information can be found in Supplementary Table 2. B Binding to hACE2-Fc over 4 weeks. Immunogens were analyzed for hACE2-Fc binding by BLI after storage at the various temperatures, normalizing against a <-70°C reference sample at each time point. C Summary of UV/vis stability data over 4 weeks, using 320/280 nm absorbance ratio as a measure of particulate scattering. D Hydrodynamic diameter and polydispersity measured by DLS over 4 weeks. Raw data provided in Supplementary File 1.

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