Fig. 3: Modi-2 SNAPvax stimulates Hcit specific CD4 responses. | npj Vaccines

Fig. 3: Modi-2 SNAPvax stimulates Hcit specific CD4 responses.

From: Modi-2 a vaccine stimulating CD4 responses to homocitrullinated self epitopes as therapy for solid cancers

Fig. 3

T cell responses to the Modi- 2 homocitrullinated and matched wild type peptides in HLA-HHDII/DP4 (A, B) and Balb/c mice (B–E). Mice were vaccinated with three doses of homocitrullinated peptides conjugated to SNAPvax and responses assessed against Hcit peptides (A, C), Hcit and wt peptides (C, D) or Hcit peptides in presence of CD4 or CD8 blocking antibodies (E). n ≥ 3 in each study and data is collated from at least two independent studies. Mean, standard deviations and significant p-values are shown.

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