Fig. 5: Serum bactericidal activity of post 3 dose rabbit serum against gonococcal isolates. | npj Vaccines

Fig. 5: Serum bactericidal activity of post 3 dose rabbit serum against gonococcal isolates.

From: Rational selection of TbpB variants yields a bivalent vaccine with broad coverage against Neisseria gonorrhoeae

Fig. 5

A–H Different N. gonorrhoeae strains were tested for bactericidal killing with the porin type, TbpB cluster, and percentage of normal human serum (NHS) used in the assay indicated above each panel. Bars represent serum bactericidal activity (SBA) Log2 titer (50% killing compared to no antibody control) for pooled pre-immune serum (black), post-dose 3 serum from rabbits immunized with a single (gray), bivalent (pink), or pentavalent (teal) TbpB variant composition. Dotted line indicates the highest dilution tested, where bars that exceed that line indicate that <50% killing was not obtained at any serum dilution tested.

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