Fig. 7: Protection conferred by the bivalent TbpB vaccine formulation against representative heterologous isolates belonging to the two gonococcal TbpB clusters in mice. | npj Vaccines

Fig. 7: Protection conferred by the bivalent TbpB vaccine formulation against representative heterologous isolates belonging to the two gonococcal TbpB clusters in mice.

From: Rational selection of TbpB variants yields a bivalent vaccine with broad coverage against Neisseria gonorrhoeae

Fig. 7

A, F Percentage of vaccinated and adjuvant controls that remain colonized over a period of 15 days after vaginal infection with a Ngo cluster 1 strain (WHO L) and cluster 2 strain (WHO F), respectively. N = 10–12 animals/group. Differences were not significant using Log-rank (Mantel–Cox) statistical test. B, G Graph depicting the number of days taken for 50% of animals to clear infection. Error bars depict the interquartile range (IQR). C, D, H, I Daily CFU recovery from the lower genital tract of infected mice. Thin gray lines depict individual animals, while thicker lines represent the average CFU recovered per day. E, J Box plot showing total bacterial burden in each animal. Bioburden was estimated using the area under the curve of Log10 transformed CFU data. *p < 0.05 obtained using two-tailed t-test, ns denotes not significant. Statistical analysis was done using GraphPad Prism 10.1.1.

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