Fig. 3: Vaccination induced HI antibody responses for A(H3N2) by number of prior years’ vaccinated.
From: Antibody responses against influenza A decline with successive years of annual influenza vaccination
A Observed post vaccination geometric mean titres (GMTs) by pre-vaccination GMT for both cell and egg-grown antigens. Data convergence on the diagonal is indicative of minimal titre rise. Red lines indicate the seropositivity threshold titre of 40. B Estimated GMT 14 d post-vaccination from the linear regression model adjusting for baseline titre, vaccine brand, age, sex, BMI and presence of any health conditions. C Estimated seropositivity 14 d post-vaccination for cell-grown antigen from the logistic regression model adjusting for baseline titre. D Estimated geometric mean titre ratios (GMR) 14 d post-vaccination from the linear regression model adjusting for baseline titre, vaccine brand, age. E Estimated proportion of HCW who seroconverted 14 d post-vaccination from the logistic regression model adjusting for baseline titre, vaccine brand, age. Panels D,E show results for cell-grown antigens only.
