Fig. 3: Clec9a recognizes actin filaments. | npj Vaccines

Fig. 3: Clec9a recognizes actin filaments.

From: Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials

Fig. 3

This finding demonstrated the role of Clec9a in recognizing F-actin structures exposed on the surface of dead cells. Upon recognition of F-actin, Clec9a initiates a signaling cascade that ultimately participates in two critical immunological processes: cross-presentation of antigens and activation of gene transcription. Created with Figdraw.com.

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