Fig. 4: Clec9a-initiated ITAM-Syk signaling cascade and downstream pathways.

Upon binding to its ligand, Clec9a triggers the Syk-ITAM signaling pathway, which in turn potentially engages multiple downstream pathways, including the Raf-1, CARD9, NIK, MAPK, NF-κB, NFAT, and ROS-NLRP3-Caspase 1 pathways. Created with BioRender.com (Agreement number: YK26UDW783).