Table 1 Comparative analysis of mouse and human Clec9a: gene structure, protein features, and immunological roles

Gene structure^50,51

7 exons spanning 13.4 kb.

6 exons spanning 12.9 kb.

Protein structure^50,51

Type II transmembrane protein, 264 amino acids, CTLD, transmembrane region, cytoplasmic tail.

Type II transmembrane protein, 241 amino acids, CTLD, transmembrane region, cytoplasmic tail.

Key role in immune system^66,109

Antigen processing in cDC1, presenting antigens from dead cells to CD8⁺ T cells.

Antigen processing in cDC1, presenting antigens from dead cells to CD8⁺ T cells.

Molecular mass⁴⁹

Predicted ~30 kDa, dimer formation

Predicted ~30 kDa, dimer formation

Structural identity⁴⁹

53% identity with human Clec9a.

Shares most structural features with mouse Clec9a.

Special characteristics⁵⁰

Additional N-glycosylation site, unique cysteine in stalk region, lacks Ca₂⁺-coordinating residues in CTLD.

Lacks Ca₂⁺-coordinating residues in CTLD, multiple sites for glycosaminoglycans.