Fig. 5: Daily temperatures of pigs.

Rectal temperatures were recorded daily for pigs immunised and boosted with GΔBDKE-CmutQ96R/K108D at different doses a 103 (Group X). b 104 (Group Y). c 102 (Group D). d Pigs immunised with 104 without a booster dose (Group C). The temperatures for the non-immune, challenge control groups were recorded following challenge with Georgia 2007/1 isolate, for (e) experiment 1 and f experiment 2. g pigs immunised with 104.5 TCID50 dose (Group E).