Fig. 3: Structural basis of HPV type-specific antibodies.
From: Establishing a universal IVRP method for quadrivalent HPV vaccines to replace in vivo potency tests
Side and top views (left panel) of cryo-EM maps of a HPV6 L1 pentamer in complex with 6-F5-77, b HPV11 L1 pentamer in complex with 11-F5-187, c HPV16 L1 pentamer in complex with 16-F5-196, and d HPV18 L1 pentamer in complex with 18-F5-203. Diagram (middle panel) of a 6-F5-77 in combination with HPV6 VLP, b 11-F5-187 in combination with HPV11 VLP, c 16-F5-196 in combination with HPV11 VLP, and d 18-F5-203 in combination with HPV18 VLP. Surface representing the interaction region between HPV VLPs and antibodies on HPV VLPs (right panel). Pink areas represent antibody binding sites, and dashed boxes represent HPV L1 pentamers. Bars at the bottom indicate the colors of HPV L1 and antibody.
