Fig. 5: Correlations between in vivo potency and in vitro potency results for Gardasil vaccine samples containing HPV6, 11, 16, and 18 VLPs. | npj Vaccines

Fig. 5: Correlations between in vivo potency and in vitro potency results for Gardasil vaccine samples containing HPV6, 11, 16, and 18 VLPs.

From: Establishing a universal IVRP method for quadrivalent HPV vaccines to replace in vivo potency tests

Fig. 5

a In vivo potency was tested by PBNA. Each column represents the mean of eight mice. b In vitro potency was tested by ELISA. Each column represents the mean of four replicates. The results plotted are from samples subjected to 56 °C heat-accelerated destruction for different intervals: 0 h, 1 h, 6 h and 12 h. Comparisons of HPV6 (c), 11 (d), 16 (e), and 18 (f) were conducted using the calculated coefficient of correlation, and statistical analyses were performed using GraphPad Prism 8.

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