Fig. 5: Immunogenicity of PV2-SC5a VLPs. | npj Vaccines

Fig. 5: Immunogenicity of PV2-SC5a VLPs.

From: Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation

Fig. 5

Dose response in neutralizing antibodies following a single immunization of Wistar rats with PV2-SC5a VLPs in either the absence or presence of adjuvant. Groups of 10 rats received PV2-SC5a VLPs at various multiples of human doses and compared to a group of 10 that were immunized with IPV as positive control. Sera were collected 21 dpi and neutralisation titres against the S19 S2 Sabin strain of PV2 was determined. Error bars represent the Geomean Standard Deviation of the data points. Statistical analysis determined by two-tailed t test in comparison to IPV (**, p value > 0.01, ***, p value > 0.001). * colour denotes the comparison group.

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