Fig. 5: Blockade of B7-H3 enhances the extent of the neoantigen-specific T-cell response to neoantigen-based cancer vaccines and local radiotherapy. | npj Vaccines

Fig. 5: Blockade of B7-H3 enhances the extent of the neoantigen-specific T-cell response to neoantigen-based cancer vaccines and local radiotherapy.

From: Targeting B7-H3 enhances the efficacy of neoantigen-based cancer vaccine in combination with radiotherapy

Fig. 5

a The mRNA levels of the exhausted T-cell marker Tim3 in resected tumors are shown (n = 3). *p < 0.05. One-way ANOVA. b The mRNA levels of the exhausted T-cell marker Tigit in resected tumors are shown (n = 3). *p < 0.05. One-way ANOVA. c The percentage of CD4+CD45+CD3+ T cells within tumors was analyzed by flow cytometry (n = 3-5). *p < 0.05. One-way ANOVA. d The percentage of CD8+CD45+CD3+ T cells within tumors was analyzed by flow cytometry (n = 3–5). *p < 0.05. One-way ANOVA. E. The percentages of CD4+CD44+CD62L-CD45+ cells (effector/memory CD4+ T cells) and CD8+CD44+CD62L-CD45+ cells (effector/memory CD8+ T cells) within tumors were analyzed by flow cytometry (n = 3-5). *p < 0.05. One-way ANOVA. f The percentage of NKp46+CD19-CD3-CD45+ cells (NKp46+ NK cells) within tumors was analyzed by flow cytometry (n = 3–5). *p < 0.05. One-way ANOVA. g The percentage of CD27+CD11b+NKp46+CD19-CD3-CD45+ cells (cytotoxic NK cells) within tumors was analyzed by flow cytometry (n = 3–5). *p < 0.05. One-way ANOVA.

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