Fig. 4: Pathway analysis of differentially essential genes under immune memory conditions. | npj Vaccines

Fig. 4: Pathway analysis of differentially essential genes under immune memory conditions.

From: TnSeq identifies genetic requirements of Mycobacterium tuberculosis for survival under vaccine-induced immunity

Fig. 4

a UpSet plots of more essential genes in each immunization condition relative to naïve mice (upper panels) and less essential genes in each immunization condition relative to naïve mice (lower panels). b Bubble heatmaps of GSEA analysis of differentially essential genes. Each bubble represents the enrichment of a gene set, defined by significantly more essential or less essential genes from an in vitro condition in MtbTnDb, against the ranked list of log2(fold-change) ratio of the TnSeq immunization condition using the GSEA preranked tool. The size of the bubble corresponds to the normalized enrichment score (NES); blue bubbles have a positive NES, and orange bubbles have a negative NES.

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