Fig. 2: Characterization and comparison of various spike mRNA LNPs made of six different cationic lipids.
From: Lipid Nanoparticle Development for A Fluvid mRNA Vaccine Targeting Seasonal Influenza and SARS-CoV-2
A Schematic of proposed mRNA Lipid nanoparticle structure. All LNPs were produced as described in “Methods”. B Weight change after immunizations. Mice (n = 5 per group) received two intramuscular injections at d0 (prime) and d14 (boost). C Anti-spike IgG at d14, d28, and d42 post prime immunizations. D Spike- specific IgG midpoint titers determined by Sigmoidal fit model from plasma titrations on Array. Statistical analysis was performed between DOTMA mRNA LNP group and other groups on each time point. *, p < 0.05; **, p < 0.01; ***, p < 0.001. Only significant p values are shown.
