Table 1 Chemical structures of six cationic lipids and colipids

From: Lipid Nanoparticle Development for A Fluvid mRNA Vaccine Targeting Seasonal Influenza and SARS-CoV-2

Cationic lipids

Structure

DOTMA

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DODMA (pKa = 6.59)

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DODAP (pKa = 5.62)

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Dlin-MC3-DMA (pKa = 6.57)

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ALC0315 (pKa = 6.09)

SM102 (pKa = 6.75)

Co-Lipids

Structure

DSPC

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Cholesterol

DMG-PEG2000

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  1. pKa of cationic lipids was determined by TNS fluorescence titration method.