Table 4 Comparison of cytokines in blood 3 h post immunizations (Vaccine groups vs Buffer)
From: Lipid Nanoparticle Development for A Fluvid mRNA Vaccine Targeting Seasonal Influenza and SARS-CoV-2
vs Buffer | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Groups | IL-6 | MCP-1 | TNF-α | IFN-γ | IFN-β | IL-1α | IL-27 | IL-23 | IL-10 | IL-1β | GM-CSF | IL-17A | IL-12p70 | |
Post Prime | HA mRNA LNP | * | * | * | * | ** | ns | ns | ns | ns | ns | ns | ns | ns |
Spike mRNA LNP | * | * | ** | ns | ns | ns | ns | ns | ns | ns | ns | ns | ns | |
HA+Spike mRNA LNP | *** | ** | * | ** | *** | * | ns | ns | ns | ns | ns | ns | ns | |
HA+Spike Protein/IVAX-1 | *** | *** | *** | ns | ns | * | ns | ns | ns | ns | ns | ns | ns | |
Post Boost | HA mRNA LNP | * | ** | * | * | ** | ns | ns | ns | ns | ns | ns | ns | ns |
Spike mRNA LNP | * | * | ** | * | ns | ns | ns | ns | ns | ns | ns | ns | ns | |
HA+Spike mRNA LNP | *** | ** | * | * | *** | ns | ns | ns | ns | ns | ns | ns | ns | |
HA+Spike Protein/IVAX-1 | * | ** | ** | **** | ns | ns | ns | ns | ns | ns | ns | ns | ns |