Table 4 Comparison of cytokines in blood 3 h post immunizations (Vaccine groups vs Buffer)

From: Lipid Nanoparticle Development for A Fluvid mRNA Vaccine Targeting Seasonal Influenza and SARS-CoV-2

 

vs Buffer

 

Groups

IL-6

MCP-1

TNF-α

IFN-γ

IFN-β

IL-1α

IL-27

IL-23

IL-10

IL-1β

GM-CSF

IL-17A

IL-12p70

Post Prime

HA mRNA LNP

*

*

*

*

**

ns

ns

ns

ns

ns

ns

ns

ns

Spike mRNA LNP

*

*

**

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

HA+Spike mRNA LNP

***

**

*

**

***

*

ns

ns

ns

ns

ns

ns

ns

HA+Spike Protein/IVAX-1

***

***

***

ns

ns

*

ns

ns

ns

ns

ns

ns

ns

Post Boost

HA mRNA LNP

*

**

*

*

**

ns

ns

ns

ns

ns

ns

ns

ns

Spike mRNA LNP

*

*

**

*

ns

ns

ns

ns

ns

ns

ns

ns

ns

HA+Spike mRNA LNP

***

**

*

*

***

ns

ns

ns

ns

ns

ns

ns

ns

HA+Spike Protein/IVAX-1

*

**

**

****

ns

ns

ns

ns

ns

ns

ns

ns

ns

  1. Kruskal–Wallis test with Dunn’s multiple groups correction was performed. ns, not significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.