Table 5 Cytokines in the overnight stimulated splenocyte cultures

From: Lipid Nanoparticle Development for A Fluvid mRNA Vaccine Targeting Seasonal Influenza and SARS-CoV-2

 

vs Buffer

 

Groups

IFN-γ

TNF-α

IL-2

IL-4

IL-5

IL-6

IL-10

IL-9 (B3)

IL-17A

IL-17F

IL-22

IL-13

HA

HA mRNA LNP

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

HA+Spike protein/IVAX-1

*

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

Spike

Spike mRNA LNP

*

ns

*

ns

*

*

ns

ns

ns

ns

ns

ns

HA+Spike protein/IVAX-1

***

**

**

ns

ns

**

ns

ns

ns

ns

ns

ns

  1. Splenocytes were isolated from mice receiving different formulations and stimulated with 10 μg/mL HA or 10 μg/mL spike for 18 h. The Statistical analysis of various groups vs Buffer is performed using Kruskal–Wallis test with Dunn’s multiple groups correction. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.