Fig. 7: Improved neutralization by antibodies obtained from glycoengineered sE2. | npj Vaccines

Fig. 7: Improved neutralization by antibodies obtained from glycoengineered sE2.

From: Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity

Fig. 7

Each datum represents the mean of duplicate experiments for each serum sample in (A) and the mean of six replicate experiments in (B). A Antibodies from the geCHO.1 line showed a 7-fold increased neutralization potency over antibodies from mice treated with the WT CHO and HEK cells for GT1a HCVpp. B Antibodies from the geCHO.1 line showed increased neutralization potency over antibodies from mice treated with the WT CHO and HEK cells for GT1a HCVcc. C Purified IgGs from the geCHO.1 line exhibited a higher frequency of cross-neutralization against HCVpp from genotypes 1b, 2a, 2b, and 3a.

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