Table 2 Recommendations and priorities for the field

From: Optimizing human B cell repertoire analyses to interpret clinical data and design sequential HIV vaccines

• Enhance antibody cloning - Implement higher throughput antibody cloning methods to sample a broader range of the vaccine-induced B cell repertoire, thereby improving cost effectiveness.

• Further automate sequencing steps: Streamline B cell-sequencing process through automation to enable rapid evaluation of various aspects of the vaccine-induced response.

• Promote collaboration: Foster close collaboration between wet-lab scientists and computational experts to continuously optimize analytical and bioinformatics workflows.

• Address population diversity: Expand genotypic testing of Ig germline genes on a global scale.

• Use Ig allelic information: Leverage Ig allelic data to select vaccine candidates to achieve broad coverage outcomes of clinical studies.

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