Fig. 3: Identification of key immune parameters associated with detectable humoral response to 2 doses of COVID-19 mRNA vaccination in SOT recipients. | npj Vaccines

Fig. 3: Identification of key immune parameters associated with detectable humoral response to 2 doses of COVID-19 mRNA vaccination in SOT recipients.

From: Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients

Fig. 3

One hundred ten individuals were recruited to a systems vaccinology study, including 20 healthy controls, 31 LTR and 59 KTR. Immunological profiles were assessed at baseline (day 0 of vaccination) for 444 immunological variables without any imputation. Multivariate logistic regression for each immunological variable was performed adjusting by sex, age, type of transplant and the number of years since transplantation, identifying the 10 highest magnitude parameters (based on log (OR of the z-score)) between significant (p-value < 0.05) associated with detectable humoral response to 2 doses of COVID-19 mRNA vaccination. A Odds ratio (OR) of the z-score of the 10 highest difference parameters (magnitude cut-off), using the stratification of SOT recipients “detectable” or “undetectable” responders according to anti-RBD binding IgG levels to 2 doses of COVID-19 mRNA vaccination. B Raw value graphs, showing healthy controls, dose 2 undetectable and dose 2 detectable responders SOT recipients, for the 10 highest magnitude parameters associated with detectable response to 2 doses of mRNA vaccination.

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