Fig. 2: Vaccination with DMCS protects from a lethal C. albicans systemic infection.
From: Pre-clinical evaluation of a divalent liposomal vaccine to control invasive candidiasis
a Scheme of BALB/c mice s.c. immunization with either HEPES buffer, empty liposomes, free Cht3:Sap2 (1:9), or DMCS (liposomes with Cht3:Sap2), and i.v. infection with C. albicans. Infection progressed similarly in the HEPES buffer and empty liposome groups (P = 0.5786), so they were combined in the Control group for clearer comparison and representation. Statistical comparisons between the control and the other immunized groups were performed thought the Log-rank (Mantel-Cox) test. b Survival curve for immunized mice after infection with C. albicans; c Average survival time for the immunization groups following infection, analyzed by one-way ANOVA. d Welfare scores for mice following infection; e Percentage weight loss of mice following infection. Endpoint values for welfare scores and weight loss are indicated by dashed lines. Significant differences are indicated by * above the lines (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).
