Fig. 2: Weight gain, clinical signs, and rectal temperatures following immunisation and challenge in all three studies. | npj Vaccines

Fig. 2: Weight gain, clinical signs, and rectal temperatures following immunisation and challenge in all three studies.

From: A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate

Fig. 2

On day 0, pigs were vaccinated with either EU-PRRSV-Con or benchmark MLV PRRS or were unvaccinated. On day 35 post-vaccination, pigs were challenged with the PRRSV-1 strains 215-06 (Study 1), 21301-19 (Study 2) or SU1-Bel (Study 3). In studies 2 and 3, groups of vaccinated pigs were left unchallenged. Following immunisation and challenge, animals were weighed on a weekly basis (A–C) and clinical signs (D–F) and rectal temperatures (G–I) were measured daily for fourteen days. Data presented as mean body weight and rectal temperatures (error bars represent the SD) or datapoints representing the clinical scores for individual pigs. Significances (p < 0.05) are described by letters where a: significant difference from EU-PRRSV-Con/challenged; b: significant difference from benchmark MLV/challenged; c: significant difference from unvaccinated/challenged; d: significant difference from EU-PRRSV-Con/no challenge; e: significant difference from benchmark MLV/no challenge.

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