Table 1 Patient characteristics

From: Diversity of immunization strongly impacts SARS-CoV-2 antibody function surrogates

 

Unvaccinated Convalescent

Vaccinated Convalescent

Vaccinated Naïve

BTI

 

Mild WT

Severe WT

WT/ChAdOx

WT/BNT

WT/BNT (2)

ChAdOx/BNT

BNT (2)

BNT (3)

BNT/BA.1

n

20

20

20

20

20

20

20

20

20

Female n (%)

15 (75)

10 (50,0)

13 (65,0)

16 (80,0)

15 (75)

10 (50.0)

15 (75)

15 (75,0)

17 (80,0)

Age at blood sampling (years). median (IQR)

28,5 (25,0–33,5)

53,0 (42,5–65,8)

32,0 (26,5–35,3)

37,5 (32,5–40,3)

31,0 (26,0–38.75)

30,5 (28,8–32,3)

34,5 (30,8–39,3)

50,5 (37,3–60,0)

45,5 (28,0–54,3)

Body mass index. median (IQR)

22,4 (20,5–24,1)

26,2 (23,8–29,1)

23,4 (21,2–26,0)

23,6 (20,7-25,9)

22,3 (19,1–24,9)

22,5 (20,8–24,1)

24,2 (21,5–29,2)

24,1 (21,8–27,0)

22,3 (21,5–24,3)

Presence of comorbidity,

* n (%)

6 (30,0)

NA

2 (10,0)

7 (35,0)

6 (30,0)

3 (15,0)

7 (35.0)

9 (45,0)

5 (20,0)

Immunization to blood sample interval (days). median (IQR)

191,5 (183,5–196,5)

292 (268,0–306,3)

218 (197,5–243,0)

185 (174,5–211,5)

224,5 (208,8–241.5)

183,5 (175,0–190,0)

190 (163,0–196,3)

184 (179,0-210,0)

190 (175,5–196,5)

# of vaccinations

NA

NA

1

1

2

2

2

3

2 (n = 7)

3 (n = 13)

  1. *Recorded comorbidities include diabetes, chronic neurological condition, hypertension, rheumatism, hypothyroidism, cancer, chronic lung disease, cardiac condition, allergy, renal disease, liver disease, sickle cell disease.
  2. WT Wuhan wild type variant, ChAdOx Chimpanzee Adenovirus Oxford nCoV-19 vaccine, BNT BioNTech 162b2, COVID-19 mRNA vaccine (ComirnatyTM), BTI (Vaccinated) Breakthrough Infection, IQR Inter-Quartile Range.