Fig. 1: FP targeting Immunogens and Immunizations.
From: Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques
a Surface representations for BG505-CH505ΔN241 and BG505-CH505 + N241, which are BG505 (Clade A)/CH505 (Clade C) chimeric trimers. The AMC016 trimer is a Clade B isolate. FP glycans are depicted as follows: N88 glycan in magenta, N230 glycan in salmon, N241 glycan in turquoise, and N611 glycan in purple. The N289 glycan is depicted in red. b Immunization schedule. Osmotic pump immunogen delivery period is shaded in pink. Bolus immunizations are depicted with triangle indicator. c Glycan Analysis of immunogens used in this study and impacts of Flag tag length on glycan occupancy.
