Fig. 5: Potent transmission reducing activity elicited by fusion antigens on ferritin nanoparticles.
From: A combined designed CSP and Pfs48/45 infection and transmission blocking vaccine for malaria
Transmission reducing activity by SMFA with purified IgG from pooled sera of immunized rabbits. a The IgG for each group at 1000 μg/mL was tested in two separate SMFAs, and the transmission reducing activity (TRA) is shown as solid lines with 95% CI (error bars). The 95%CI and statistical significance were calculated by the zero-inflated negative binomial model (ZINB model) with Bonferroni corrections. b Ferritin nanoparticle groups were tested at lower IgG concentrations to quantitatively compare their potency. Symbols indicate TRA values with 95% CI error bars. Data at 1000 and 333 μg/mL come from two separate SMFAs, and all other data comes from a single feed.
