Fig. 2: WRAIR down-selection challenge studies indicate that minor repeat- and junctional+minor repeat-focused vaccines do not improve upon major repeat-focused vaccines. | npj Vaccines

Fig. 2: WRAIR down-selection challenge studies indicate that minor repeat- and junctional+minor repeat-focused vaccines do not improve upon major repeat-focused vaccines.

From: Comparison of major, minor and junctional circumsporozoite protein epitopes for malaria vaccine design

Fig. 2

Addavax-adjuvanted vaccines were administered to C57Bl/6 mice (n = 10). A–D First study (three 2.5 µg antigen doses); E–H second study (three 5 µg antigen doses). A, E Schematic of study outline showing vaccination and sera collection time-points. Challenge via intravenous administration of transgenic PbPf sporozoites occurred 3 weeks post-third dose (3WP3). B, F Geometric mean ELISA titer (OD415 nm = 1) with 95% confidence intervals using 2WP3 sera. Red symbols denote protected mice. C, G FL-CSP avidity (mean of duplicate wells) measured using pooled group sera at 2WP3. Plotted values are the molarity of sodium thiocyanate required to reduce the maximal OD415 nm by 50%. D, H Survival curves after intravenous challenge with 3000 transgenic PbPf parasites.

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