Fig. 5: Epitope mapping and CBASQE quantitation of functional binding for 2WP3 vaccine sera. | npj Vaccines

Fig. 5: Epitope mapping and CBASQE quantitation of functional binding for 2WP3 vaccine sera.

From: Comparison of major, minor and junctional circumsporozoite protein epitopes for malaria vaccine design

Fig. 5

A Geometric mean ELISA titer with 95% confidence intervals of Addavax-adjuvanted first screened against using peptides NANPx6 (major repeat, abbreviated as MAJ), peptide 22 (minor repeat, abbreviated as MIN) and peptide 21 (junctional, abbreviated as JUNC). B CBASQE-based quantitation of mAb 317, mAb CIS43, and mAb L9 competition (median ng/mL with 95% confidence intervals) for Addavax-adjuvanted vaccines. C CBASQE assay using select sera from JHU study 1 showing comparison of TMV vaccines to RTS,S/AS01. D CBASQE assay using sera from JHU study 2 showing comparison of T5 and cGMP T20 vaccines to RTS,S/AS01.

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