The DNA mutation that causes Duchenne muscular dystrophy in mice can be corrected, with minimal off-target effects, by gold nanoparticles carrying the CRISPR components.
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References
Hsu, P. D., Lander, E. S. & Zhang, F. Cell 157, 1262–1278 (2014).
Doudna, J. A. & Charpentier, E. Science 346, 1258096 (2014).
Tabebordbar, M. et al. Science 351, 407–411 (2016).
Nelson, C. E. et al. Science 351, 403–407 (2016).
Long, C. et al. Science 351, 400–403 (2016).
Lee, K. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-017-0137-2 (2017).
Ramadasan-Nair, R. et al. J. Biol. Chem. 289, 485–509 (2014).
Wang, M., Glass, Z. A. & Xu, Q. Gene Ther. 24, 144–150 (2017).
Wang, H.-X. et al. Chem. Rev. 117, 9874–9906 (2017).
Yin, H., Kauffman, K. J. & Anderson, D. G. Nat. Rev. Drug Discov. 16, 387–399 (2017).
Staahl, B. T. et al. Nat. Biotechnol. 35, 431–434 (2017).
Zuris, J. A. et al. Nat. Biotechnol. 33, 73–80 (2015).
Wang, M. et al. Proc. Natl Acad. Sci. USA 113, 2868–2873 (2016).
Ran, F. A. et al. Nat. Protoc 8, 2281–2308 (2013).
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Glass, Z., Li, Y. & Xu, Q. Nanoparticles for CRISPR–Cas9 delivery. Nat Biomed Eng 1, 854–855 (2017). https://doi.org/10.1038/s41551-017-0158-x
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DOI: https://doi.org/10.1038/s41551-017-0158-x
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