Neuropathologies can be classified, on the basis of post-mortem histopathology and by using machine learning, into six transdiagnostic clusters associated with clinical phenotypes.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective
Journal of Translational Medicine Open Access 23 May 2025
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout

Change history
12 February 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41551-020-00628-2
References
Soria Lopez, J. A., Gonzalez, H. M. & Leger, G. C. Handb. Clin. Neurol. 167, 231–255 (2019).
Butler, P. M. & Chiong, W. Handb. Clin. Neurol. 163, 391–410 (2019).
Kovacs, G. G. Handb. Clin. Neurol. 145, 355–368 (2017).
Alafuzoff, I. & Hartikainen, P. Handb. Clin. Neurol. 145, 339–353 (2017).
Peng, C., Trojanowski, J. Q. & Lee, V. M. Nat. Rev. Neurol. 16, 199–212 (2020).
Elahi, F. M. & Miller, B. L. Nat. Rev. Neurol. 13, 457–476 (2017).
Karanth, S. et al. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2020.1741 (2020).
Cornblath, E. J. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-020-0593-y (2020).
Toledo, J. B. et al. Alzheimers Dement. 10, 477–484 (2014).
Ransohoff, R. M. Science 353, 777–783 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
P.V. owns stocks and has received consultancy fees from Accure Therapeutics, Health Engineering, QMENTA, Attune Neurosciences, CLight, NeuroPrex and Spiral Therapeutics. These companies are not associated with this work. J.C.M. has received consultancy fees from Biogen and is on their Speaker Bureau, and has received research support from AbbVie, Biogen, Esai, Eli Lilly and Company, and Novartis. R.B.-Y. declares no competing interests.
Rights and permissions
About this article
Cite this article
Villoslada, P., Baeza-Yates, R. & Masdeu, J.C. Reclassifying neurodegenerative diseases. Nat Biomed Eng 4, 759–760 (2020). https://doi.org/10.1038/s41551-020-0600-3
Published:
Issue date:
DOI: https://doi.org/10.1038/s41551-020-0600-3
This article is cited by
-
Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective
Journal of Translational Medicine (2025)
-
A data-efficient strategy for building high-performing medical foundation models
Nature Biomedical Engineering (2025)