Extended Data Fig. 1: Overall process of rapid haemostatic tissue sealing by the barnacle-glue-inspired paste.
From: Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue
(Step 1 and 2) The barnacle-glue-inspired paste can be applied directly on bleeding injury without any other preparation process; (Step 3 and 4) On application of gentle pressure, the silicone oil matrix in the barnacle-glue-inspired paste repels and clean blood from the bleeding injury; (Step 5 and 6) Simultaneously, the carboxylic acid groups in the bioadhesive microparticles form temporary physical crosslinks by hydrogen bonds, followed by the covalent crosslinking between the NHS ester groups and the primary amine groups with themselves and the tissue surfaces; (Step 7) the swollen and crosslinked paste provides robust haemostatic tissue sealing.
