Extended Data Fig. 1: Synthesis strategy for antibody-sensor conjugates for biodistribution of antibody and GzmB cleavage. | Nature Biomedical Engineering

Extended Data Fig. 1: Synthesis strategy for antibody-sensor conjugates for biodistribution of antibody and GzmB cleavage.

From: Urinary detection of early responses to checkpoint blockade and of resistance to it via protease-cleaved antibody-conjugated sensors

Extended Data Fig. 1

a, Synthetic scheme of antibody-sensor conjugate labelled with near infrared fluorophore VT750 to determine antibody biodistribution. b, Synthetic scheme of NIR activatable GzmB probe, consisting of fluorescently quenched GzmB substrate conjugated to αPD1 antibody.

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