Extended Data Fig. 1: Clinical Cerenkov imaging system based on the Lightpoint fiberscope design. | Nature Biomedical Engineering

Extended Data Fig. 1: Clinical Cerenkov imaging system based on the Lightpoint fiberscope design.

From: Prospective testing of clinical Cerenkov luminescence imaging against standard-of-care nuclear imaging for tumour location

Extended Data Fig. 1

a) The Cerenkov camera (Andor iXon Ultra 897 EMCCD, Andor Technology Ltd., Belfast, UK) enclosed in a lead shielded box (background) with a connecting fiberscope to a preclinical enclosure (foreground). b) Clinical enclosure (Lightpoint Medical Ltd., Chesham, UK) containing a reclining chair for patient imaging. The fiberscope (Lightpoint Medical Ltd., Chesham, UK) is installed through the rear of the enclosure opposite the dual track shroud system (red box inset). The fiberscope is held in place via a three-axis articulating arm containing a cerrobend baffle to reduce gamma and beta strikes to the fiber (green box inset). A 17 mm C-mount lens with an f# of 0.95 was used to collect CL (Xenon 0.95/17, Jos. Schneider Optische Werke GmbH, Bad Kreuznach, GM) c) Example of both shrouds deployed to prevent ambient light from reaching the patient during CLI.

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