Extended Data Fig. 1: CAR-receptor diversity in different tumour models. | Nature Biomedical Engineering

Extended Data Fig. 1: CAR-receptor diversity in different tumour models.

From: Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy

Extended Data Fig. 1

a, The number of unique scFv clones derived CAR+ cells sorted from different animal models. b, Oligoclonality of the various libraries as represented by the top ten most abundant clones in each library. The x-axis displays the clones in decreasing abundance, while the y-axis represents the abundance (as a percent of sequencing reads) of the corresponding clones. c, Comparison of high-frequency heavy chain CDR3s (CDRH3s) reveals unique VH genes in each of six mice treated with CAR library. Heat map showing the distribution of highly represented CDRH3s in different animals. The y axis represents the ten highest frequency CDRH3 sequences identified in each mouse. The x-axis compares the frequency of these prevalent CDRH3 sequences across all other mice. d, Density plots of the distribution of CDRH3 amino acid lengths of the scFv clones for the various libraries.

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