Extended Data Fig. 5: Differential gene expression between Var1 and 19BBζ-expressing CAR-T cells. | Nature Biomedical Engineering

Extended Data Fig. 5: Differential gene expression between Var1 and 19BBζ-expressing CAR-T cells.

From: Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains

Extended Data Fig. 5

Volcano plot showing differentially expressed genes between Var1 (n = 863 cells) and 19BB𝛇-expressing (n = 637 cells) CAR-T cells 48 hours after a third NALM6 rechallenge. P values for each gene were determined using a two-sided Wilcoxon Rank-Sum test. Genes with both a Bonferroni-corrected P value less than 0.05 and an average log2FC of > 1 are highlighted.

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