Extended Data Fig. 6: High dose Var1, Var3, and BBζ achieve sustained remission. | Nature Biomedical Engineering

Extended Data Fig. 6: High dose Var1, Var3, and BBζ achieve sustained remission.

From: Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains

Extended Data Fig. 6

a, Experimental design. NSG mice were infused intravenously with 5 × 105 FLuc+ CD19+ NALM6 cells, then treated i.v. with 1 × 106 of a 1:1 mixture of human CD8+ and CD4+ CAR-T cells or untransduced control T cells (n = 5 mice for all groups). b, Kaplan-Meier curve for overall survival. Tumour burden was assessed by measuring luminescent activity. c, Quantification of total photon counts are shown. d, Weight loss following ACT was monitored routinely. Data shown in panels (c,d) are individual values.

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