Extended Data Fig. 2: Gene expression of genes related to fatty acid absorption and processing. | Nature Biomedical Engineering

Extended Data Fig. 2: Gene expression of genes related to fatty acid absorption and processing.

From: Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction

Extended Data Fig. 2

Transcriptional pathway analysis revealed a strong theme of downregulation for genes related to fatty acid absorption and processing when EED chips were exposed to -N/-T media. This included a 4.7-fold downregulation of CIDEC (q < 0.001), a 4.9-fold downregulation of CREB3L3 (q < 0.001) and a 7.7-fold downregulation of PCK1 (q < 0.001), which are shown as the log2 fold change between the average expression levels along with the associated 95% confidence interval. 3 chips for each condition. Each chip corresponds to one biological replicate. **, p < 0.01; ***, p < 0.001.

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