Extended Data Fig. 8: Ex vivo human skin wound-healing model with pre-tension.

a-c, Ex vivo human skin with speckles and corresponding digital image correlation (DIC) analysis results without pre-tension (a) and with pre-tension in x-direction (b) and in y-direction (c). ROI, region of interest. d,e, Representative images of an ex vivo human skin culture setup with pre-tension before (d) and after (e) the strain-programmed patch application. f, Quantification of the open wound length on day 4 (D4) post-injury. Values in f represent the mean and the standard deviation (n = 9 wounds for No Strain and 13 wounds for Strain from 2 individual patients’ skin; independent samples). Statistical significance and p values are determined by two-sided t-test. Scale bars, 5 mm (d,e).