Extended Data Fig. 5: In vivo Aβ imaging with vMSOT.
From: Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice
a, 3D rendering of vMSOT data in arcAβ mouse brain unmixed for AOI987 distribution. b, Baseline-subtracted single wavelength vMSOT image acquired at 650 nm. c, Image acquired at 600 nm excitation wavelength reveals the major cerebral vessels. d, Overlay of a and c. e,g, Overlay of a on MRI structural data. f, Time-lapse curve of the unmixed AOI987 absorbance. h, The corresponding curve for the baseline-subtracted signal at 650 nm. AOI987 was injected i.v. at 30 s. The temporal evolution of the unmixed AOI987 absorbance and baseline-subtracted signals was analysed in four different brain regions: cortex (red), superior sagittal sinus (green), hippocampus (blue), vessel (grey) on the cortical surface indicated in e,h. norm, normalized; ab, absorbance.
