Fig. 4: Visual detection of SARS-CoV-2 RNA mutations. | Nature Biomedical Engineering

Fig. 4: Visual detection of SARS-CoV-2 RNA mutations.

From: A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution

Fig. 4

a, V367F, R408I and mutations in VOCs. b, Mutation information of VOCs including Alpha, Beta, Gamma and Delta variants. c, Design and validation pipeline for TEprobes targeting mutations of interest in the SARS-CoV-2 genome. d, Visual detection of mutations listed in a. e, MARVE can distinguish the SARS-CoV-2 D614G variant from wild SARS-CoV-2 at up to a 50-fold molar excess of the variant. The green shadow indicates the range of discrimination factors. The concentration of the SARS-CoV-2 D614G variant was 30,000 copies per μl. The concentration of SARS-CoV-2 pseudovirus was 30,000 copies per μl in d. Data in d and e are mean ± s.d. (n = 3).

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