Extended Data Fig. 4: Viral genome distribution of AAV.CPP.16 vs. AAV9 in BALB/cJ. | Nature Biomedical Engineering

Extended Data Fig. 4: Viral genome distribution of AAV.CPP.16 vs. AAV9 in BALB/cJ.

From: Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood–brain barrier in rodents and primates

Extended Data Fig. 4

5 × 1011 vg AAVs-CAG-GFP-WPRE were intravenously injected to BALB/cJ mice and AAV genomic DNA was isolated 21 days later. AAV viral genomes in selected CNS regions (a) and peripheral organs (b) were measured by qPCR using primers targeting WPRE and normalized to mouse genome (targeting glucagon). n = 4 mice per group, mean ± s.e.m., Student’s t-test.

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