Extended Data Fig. 3: Brain transductions by AAV.CPP.16 and AAV.CPP.21 in four common mouse strains. | Nature Biomedical Engineering

Extended Data Fig. 3: Brain transductions by AAV.CPP.16 and AAV.CPP.21 in four common mouse strains.

From: Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood–brain barrier in rodents and primates

Extended Data Fig. 3

a-l, Representative fluorescence images of brain regions in C57BL/6J, BALB/cJ, FVB/NJ and 129S1/SvlmJ mice 21 days after intravenous injection of 1 × 1011 vg of AAVs-EF1α-H2B-RFP (AAV9, a-d; AAV.CPP.16, e-h; AAV.CPP.21, i-l). White dots indicate RFP-positive cells. Scale bars: 500 μm. m, quantification of transduced brain cells in C57BL/6J at a high dose of AAVs (1 × 1012 vg, IV). n = 3 mice per group, mean ± s.e.m., one-way ANOVA with Tukey’s post-test.

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