Extended Data Fig. 4: Comparison of MS/MS spectra from both Orbitrap and qTOF instruments. | Nature Biomedical Engineering

Extended Data Fig. 4: Comparison of MS/MS spectra from both Orbitrap and qTOF instruments.

From: Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics

Extended Data Fig. 4

Back-to-back comparison of DDA (top panels, HCD, Orbitrap, 1.6 m/z window) and DIA (bottom panels, CID, qTOF, 2 m/z window) MS/MS spectra for each of the candidate glycopeptides from the COVID-19 cohort. For CID/HCD spectra, fragments matched to theoretical fragments exported from Byonic for each DDA spectrum are shown (0.1 Da tolerance). Fragments shared between DDA and DIA spectra are shown in blue, oxonium ions in red and singly-assigned fragments in grey.

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