Extended Data Fig. 2: Efficacy of VasES in directing the migration of SVZ newborn neurons by histology assessment. | Nature Biomedical Engineering

Extended Data Fig. 2: Efficacy of VasES in directing the migration of SVZ newborn neurons by histology assessment.

From: Laminin-coated electronic scaffolds with vascular topography for tracking and promoting the migration of brain cells after injury

Extended Data Fig. 2

a, b, and c represent control probe, VasES without laminin, and VasES, respectively. I, II and III show topographical design, surface functionalization and fluorescence images, respectively, at 1 week post-implantation. The insets feature larger area images, with the SVZ and the volumes used for quantification of DCX intensity outlined by white and yellow contours, respectively. Scale bars, 100 µm. d, Comparison of normalized DCX fluorescence intensity within 60 µm from control probes (N = 4), VasES without laminin functionalization (N = 3), and VasES with laminin functionalization (N = 3) at 1 week post-injection (details in the Supplementary Note 3). Independent samples were collected from different mice for each group. Error bars represent ±1 s.d. **P = 1.02 × 10−3 (control versus VasES), *P = 1.61 × 10−2 (control versus VasES without laminin), *P = 1.70 × 10−2 (VasES without laminin versus VasES); two-tailed t-test.

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